China CAS 189188-57-6,Tegaserod Maleate,CAS 189188-57-6,Tegaserod Maleate Manufacturer
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We,ChinaTegaserod Maleate Suppliers and China 22795-99-9 Tegaserod Maleate Cas No.189188-57-6
Manufacturers with quality you can count on including those with CAS number189188-57-6, You can be assured that all Tegaserod Maleate 189188-57-6 offered byVolsen, meet or exceed the grade requirements or specifications for each individual product.
Usage: 1.A gastroproeinetic use in the treatment of irritable bowel syndrome.
2.A selective serotonin 5HT4-receptor partial agonist
COA Specification of Tegaserod Maleate Cas No.189188-57-6
|
Items |
Specifications |
Results |
|
Appearance |
A White powder |
Conform |
|
Identification |
HPLC IR |
Conform |
|
Solubility |
Scarcely soluble in water, sparingly soluble in methanol, slightly soluble in ethanol and scarcely soluble in chloroform |
Conform |
|
Methanol |
≤0.30% |
Conform |
|
Melting Point |
188.0°C ~193.0°C |
188.5°C~190.5°C |
|
Loss on drying |
≤0.50% |
0.16% |
|
Residual on ignition |
≤0.10% |
0.07% |
|
Heavy Metals |
≤10ppm |
Conform |
|
Residual solvent |
Ethanol≤5000ppm Methanol≤3000ppm |
Conform Conform |
|
Related Substances(HPLC) |
Single impurity≤0.3% Total impurities≤1.0% |
0.08% 0.13% |
|
Assay(based on drying) |
≥99.0 |
99.3% |
|
Particle size |
50%≤70microns 90%≤205microns |
Conform Conform |
|
Conclusion: The product corresponds to the requirements of in house standard. |
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Storage Condition: Keep container tightly closed in a dry and well-venting place.
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Tegaserod is a 5-HT4 agonist manufactured by Novartis and sold under the name Zelnorm for the management of irritable bowel syndrome and constipation.
Mechanism of action
The drug functions as a motility stimulant, achieving its desired therapeutic effects through activation of the 5-HT4 receptors of the enteric nervous system in the gastrointestinal tract. It also stimulates gastrointestinal motility and the peristaltic reflex, and allegedly reduces abdominal pain. Additionally, tegaserod is a 5-HT2Breceptor antagonist.
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